Chelsea manager, Frank Lampard, will make a late decision on N'Golo Kante before the game at Old Trafford.
The France midfielder hopes to return following a knee injury while Forward Willian and Defender Antonio Rudiger (both knee) also face fitness tests but are unlikely to feature.
Christian Pulisic could make his Blues debut, following his £58million move from Borussia Dortmund.
But England duo, Ruben Loftus-Cheek and Callum Hudson-Odoi (both Achilles) will be unavailable.
Chelsea's provisional squad:
Goalkeepers: Arrizabalaga, Caballero
Defenders: Azpilicueta, Zappacosta, Rudiger, Tomori, Christensen, Zouma, Alonso, Palmieri
Midfielders: Jorginho, Kante, Barkley, Kovacic
Attackers: Mount, Kenedy, Pedro, Willian, Pulisic, Giroud, Abraham, Batshuayi.